AS involves the proliferation and migration of smooth muscle cells, monocytes, and T-lymphocytes, and cholesterol accumulation, among other factors (Gui et al., 2012)
Elevated levels of ANGPTL4 and c-GAS-STING pathways are associated with macrophage polarization and accumulation in the diabetic kidney (Srivastava et al., 2024
In addition, the brain is susceptible to oxidative stress because its high in fat, which can oxidize or go rancid. The brain is also high in iron and zinc, which can further fuel oxidative stress
Where you may have seen it: Tirzepatide is available under brand names like Mounjaro and Zepbound, both of which are used for weight management and improving metabolic health
The main safety concern isnt the GLP-1 itself
Seo YS, Yim SY, Jung JY, et al