More than half of patients (53%) stop using GLP-1s within the first year, according to a December 2025 Sermo survey of physicians
Taking high-dose supplements over 1,000 mg per day may also increase the risk of kidney stones in predisposed people ( Benefits of Supplements There is mixed evidence that vitamin C supplements benefit people who get adequate amounts from the diet
For instance, she points out that a 2012 study published in the Journal of Cosmetics, Dermatological Sciences and Applications noted a test group in which individuals who took B5 supplements experienced a significant reduction in facial blemishes and facial lesions without negative side effects
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Summary Keywords body composition, GLP-1 receptor agonists, gutbrain axis, lean mass preservation, postbiotics, resistance training, short-chain fatty acids, weight regain Citation Cengiz Kaynakc E (2026) Potential role of postbiotics in supporting lean mass preservation and weight-loss sustainability during GLP-1based anti-obesity therapy
Stabilization of cell membranes L-carnitine is also essential in maintaining membrane stability and the function of plasma, mitochondria, and other organelles, probably through its effects on the acetylation of membrane phospholipids
