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GLP-1 receptor agonists versus Metformin in PCOS: a systematic review and meta-analysis

We focus on newer metabolic treatments such as Tirzepatide

GHK-Cu reduces oxidative stress by increasing the activity of antioxidant enzymes

This is in line with the fact that E vitamin fortification promotes the synthesis of good lipids, lowers insulin levels, and helps to counteract the harmful oxidation process in PCOS [134]

If the observed benefit of GLP-1 receptor agonists disappears or weakens meaningfully when compared with another contemporary metabolic therapy, then the story becomes less about a unique anticancer effect and more about broader metabolic optimization, comparator selection, or residual differences between treatment populations

In contrast, under conditions of restricted protein supply, the remethylation pathway is favored by an acceleration of the MTHFR-dependent folate mobilization (Fig