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Its activation elevates the expression of key lipogenic genes, such as FASN, ACLY, and ACC

doi: 10.5826/dpc.0601a07

Conversely, in this study we also found that a reduction in mouse islet cholesterol levels with simvastatin, which disrupts ER cholesterol synthesis by inhibiting HMGCR enzymatic activity (4446), increased exendin-4-mediated cAMP and insulin secretion responses