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This finding should be viewed in the wider context of the existing premise that high plasma cystine is a marker of oxidative stress: studies have linked high cystine and low rGSH to multiple adverse outcomes, including CVD pathogenesis (Go and Jones 2011), renal disease progression (Rodrigues et al

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[DOI] [PubMed] [Google Scholar] 5.Mascagni P., Consonni D., Bregante G., Chiappino G., Toffoletto F

This hypothesized mechanism may be further tested by examining the total intracellular platinum and DNA-bound platinum in BTC cells following treatment with BSO in combination with cisplatin