Experts increasingly advocate aligning safety expectations for high-risk probiotic products (e.g., LBPs) with those applied to other complex biologicals, including systematic genomic characterization, standardized adverse-event reporting, and structured post-market surveillance, while avoiding unnecessarily stricter requirements than for comparable biologic therapies (525)
Fecal microbiome transplantation from PTSD adolescents into germ-free mice induced significant anxiety behaviors, confirming functional contribution of gut microbiota to psychiatric symptomatology (Yirmiya et al., 2024)
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