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Effect of basal insulin glargine on first and recurrent episodes of heart failure hospitalization: the ORIGIN trial (Outcome Reduction with Initial Glargine Intervention)

Clinical studies demonstrate significant weight loss, averaging 15% over 68 weeks

Nausea represents the most frequently reported adverse reaction, affecting a significant proportion of patients, particularly during the initial weeks of therapy or following dose increases

However, more research is needed to know its long-term effects and safety

ArticlePubMed 25

Reduced inflammatory signaling protects dermal and epidermal cells from damage and slows matrix degradation