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doi: 10.1007/s40279-015-0408-6

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This reduction in FGF18 protein stabilization decreases its interaction with SNF2 related chromatin remodeling ATPase 5 (SMARCA5), thereby repressing the chromatin accessibility of the SMAD family member 4 ( SMAD4 ) promoter and activating the SMAD4-dependent pathway [102]

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Standardization deficiencies compound these issues throughout therapeutic pipeline