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Hemolytic anemia was reported to be significantly more severe with G6PD Mediterranean and Cairo compared to G6PD A-, indicating a direct positive correlation between enzyme deficiency and severity of clinical manifestations
Despite their notable absence in CM, alterations in the SF3B1 gene are not unique to MM - similar mutations have also been detected in uveal melanoma, breast cancer, myelodysplastic syndromes, and chronic lymphocytic leukemia, including mutation hotspots such as codon 700, 622, 625, 662, and 666 (99, 113)
Commonly reported side effects can include mild pain or some bruising where the injection is given, allergic reactions such as rashes or itching, and occasionally nausea or stomach discomfort
Amodei, L., Ruggieri, A
Doi: 10.1007/s12011-013-9712-x
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