glutathione glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases Glutathione - an overview |

These data re-enforce preclinical studies that suggest the antioxidant and anti-inflammatory activities of ergothioneine interfere with atherogenesis and protect vascular and microvascular endothelial cells from oxidative stress and hyperglycaemia (81)

doi: 10.1172/JCI118077

Adachi M, Barrot M, Autry AE, Theobald D, Monteggia LM

Mitochondrial electron transport chain, ROS generation and uncoupling

Studies document accelerated collagen remodeling and improved structural recovery in Achilles tendon injuries PMID: 25415472

Specifically, HC induced a significant change in 15 proteins (i.e., 9 and 6 up- and down-regulated, respectively) involved in autophagy, including the down-regulation of NPC1 (Nieman-Pick type C) and QSOX1 (quiescin sulfhydryl oxidase 1) and the up-regulation of HMOX1 (heme oxygenase 1) and KDM4A (lysine demethylase 4A)