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This neuroinflammatory response was accompanied by reduced expression of tight junction proteins in the BBB, suggesting that systemic inflammation originating from the gut directly impacts BBB permeability and brain inflammation

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Realistic timelines matter: expect initial brightening within 4-8 weeks , with significant dark spot fading around 3-4 months as pigmented cells shed through multiple turnover cycles

In animal models, both processes are essential for tissue regeneration, providing the theoretical basis for studying them in combination

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