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[20] [21] There has been scientific evidence that chelation therapy for heart disease is modestly successful

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More specifically, several recurring TME features are particularly relevant to nanotherapeutic design: abnormal vasculature, dense stroma and an immunosuppressive immune landscape [10,11,12,13,14]

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Cases with more substantial DLB disease have typical symptoms, whereas cases with larger neurofibrillary tangles are likely to show AD (Simard et al., 2000)