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Moreover, pyruvate dehydrogenase kinase 4 (PDK4), localized to the IMM, has been implicated in metabolic regulation of ferroptosis by inhibiting pyruvate oxidation and altering lipid metabolic pathways, thereby modulating lipid peroxidation-dependent ferroptotic vulnerability [91] (Fig

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It appeared to lower the intensity of H2AX signals a marker of DNA damage and seemed to decrease apoptosis rates, as indicated by reduced Annexin-V staining

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