Caloric restriction reduces the generation of growth hormone, insulin, IGF1, and other growth factors, all of which have been shown to hasten aging and increase mortality in a number of species (see Figure 3 ) (206)
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In other words, weight loss results in an improvement in muscle composition but a decline in muscle volume
The path to maximizing the benefits of this innovative treatment involves careful preparation and aftercare
Once people stop taking these drugs, most seem to regain their lost weight