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Given the impairment in DPP4i action evident in HFD-fed mice, we wondered whether DPP-4 inhibition retained its hypolipidemic actions in older mice

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Several naturally occurring mutations of ghrelin receptor , such as A204E and F279L, decrease the basal activity of the receptor and have been found to associate with obesity, diabetes, and short stature 14 , which led to the idea of ghrelin receptor being an attractive therapeutic target for these diseases

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GLP-1RA treatment also mitigates experimental diabetic cardiomyopathy by the indirect mechanisms of augmenting glucose oxidation in cardiomyocytes [84]