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Reducing dose of insulin secretagogue or insulin may be necessary Acute Kidney Injury: Monitor renal function in patients with renal impairment reporting severe adverse gastrointestinal reactions Hypersensitivity Reactions: Serious hypersensitivity reactions (e.g., anaphylaxis and angioedema) have been reported

Lawrence and Burk subsequently modified this protocol for specialized applications, including the assessment of GPx activity in liver supernatants from selenium-deficient experimental models [22]