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Since mitochondrial metabolism is prevalent in normal high-energy-demand tissues, such as the heart and liver, OXPHOS inhibitors (e.g., IACS-010759) have shown dose-limiting toxicities (DLT) in some clinical trials, hindering their widespread application [173]
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Together, these data identify a highly conserved putative TFAP2 motif within the glp-1 promoter that is important for the regulation of glp-1 expression and germ cell fate
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always follow the device-specific instructions provided by your clinical trial team, and ensure you have received hands-on training before self-injecting
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