Retatrutide activates three, targeting GLP-1, GIP, and glucagon receptors simultaneously, which is why Eli Lilly calls it a "triple agonist." This triple mechanism is also why the dose schedule matters more than with any other weight loss peptide on the market
At 12 months, weight loss persisted at around 4%, with variability between agents, most notably liraglutide
That is why the honest answer to are glp patches legit depends on what you mean
In terms of appetite suppression onset, many patients report that tirzepatide produces noticeable effects slightly faster, likely due to its dual GIP/GLP-1 mechanism
Each row is a receptor, each column a molecule
De Marinis, Y