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CGRP represents the most intriguing biological mechanism, linking the nervous system to bone repair, but direct therapeutic application is complicated by its role in pain signaling and the current clinical use of CGRP-blocking agents for migraine treatment

Low-fat areas such as the inner thigh, the lower abdomen in leaner individuals, and sites near bony prominences should be avoided where possible as they offer less tissue cushioning and produce more pronounced discomfort

Maintenance therapy for patients with neurological involvement may also be more frequent, sometimes every two months rather than three, though this should be individualised based on clinical response

Previous studies implicate MB in both memory enhancement and neuroprotection

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