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Hass DT, Pandey K, Engel A, et al

Int J Oncol 2014

Using intracranial injections of a lentiviral short hairpin RNA (shRNA) construct to lower Gsto2 selectively in iSPNs of Trkb mutant mice prevented the dopaminergic dysfunction, improved energy metabolism, and other molecular rescues

As GLP-1(7-36)NH 2 , the endogenous ligand for GLP-1R, is enzymatically inactivated in the circulation within minutes and eliminated by glomerular filtration, a number of strategies have been used to develop pharmaceutically viable peptide GLP-1R agonists (GLP-1RAs) which remain active in the circulation for hours or days (A Andersen et al ., 2018)