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Through this mechanistic framework, the SL perception machinery may also be sensitive to additional regulatory layers, such as the controlled co-expression of the dozens of proteins involved in substrate ubiquitination and degradation 77 , small molecules (e.g., citrate or inositol phosphates) 19,48,51 or post-translational modifications 78

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The intracellular core-congeries supplied efficient signal enlargement, fluorescence gathering and enabled super-sensitive monitoring of GSH levels

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