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GLP-1 receptor agonist (RA) medications work by mimicking natural hormones that promote feelings of fullness, helping to reduce calorie intake

GIP enhances the metabolic flexibility allowing tissues to utilize both glucose and fatty acids efficiently

Leveraging the University of California Health Data Warehouse enabled a realworld analysis of 6,871 patients with primary colon cancer and rigorous adjustment strategies to probe whether GLP1 RA exposure relates to fiveyear mortality. At the end of the study, researchers found that participants with colon cancer taking GLP-1 medications had a 15.5% mortality risk within 5 years, compared to 37.1% in participants not taking the drugs

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What are the common side effects of GLP-1 therapies

But they also represent one of the most significant cost risks to employer health insurance plans heading into the 2026 renewal cycle