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Their study in male mice and macaques demonstrated that IMA-1 disrupts the arachidonate 12-lipoxygenaseacetyl-CoA carboxylase 1 interaction, thereby treating NAFLD without inducing hyperlipidemia [74]

Tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in systemic inflammation, along with matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) enzymes that break down extracellular matrix proteins might potentially influence both the inflammatory processes and the remodeling of tissues

10.14348/molcells.2016.2318 28 Bou-TeenD.KaludercicN.WeissmanD.TuranB.MaackC.Di LisaF.et al (2021)