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10.1016/j.metabol.2021.154734 3 EbrahimN.ShakirovaK.DashinimaevE

Prolactin elevation similarly confounds reproductive, immune, and metabolic research endpoints, as prolactin receptors are expressed across a wide tissue distribution including liver, adipose, and immune cells

Uremic toxins, oxidative stress, and mitochondrial dysfunction seen in CKD contribute to the activation of the NLRP3 inflammasome, promoting macrophage-mediated inflammatory responses and subsequent vascular injury

Simple enough to build a consistent habit around

Supplements are safer, cheaper, and more accessible but approximately 5x less effective for weight loss

Literature search A comprehensive literature search was conducted in May 2025 across PubMed, Embase via OVID and the Cochrane Library from 01 January 2015 to 12 May 2025