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Instead, it is a response to rapid changes the body is undergoing

Severe uncontrolled high blood pressure

Clinical Update 5/31/2024 Coffee Intake & Osteoporosis Drinking coffee was linked with a lower risk of osteoporosis in a recent study, but the amount and type of coffee both appear to matter

None of the reported adverse reactions of peripheral edema resulted in trial drug discontinuation

The mechanism involves IGF-1-mediated stimulation of osteoblast proliferation and enhanced collagen synthesis in bone matrix

[2] [9] These effects are typically dose-dependent, most pronounced during dose escalation, and tend to diminish over time as patients develop tolerance