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Drug Discovery 9, 18

Data was acquired using Thermo Xcalibur 4.0 Software (Thermo Scientific, Waltham, MA USA) MS data processing and analysis were made using Skyline software (V20, MacCoss Lab, University of Washington, Seattle, WA)

It can resemble a melanotic macule, showing melanin accumulation in the basal cell layer, or it may result from the deposition of drug-related metabolites as fine brown-yellow granules within the lamina propria [11,12]

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