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CMAJ 193(16):E561 Buchner A, Hansen LS (1979) Melanotic macule of the oral mucosa

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Early analysis from a phase 3 REDEFINE 1 trial showed the once-weekly Cagrilintide monotherapy injection helped patients reduce their weight by 11.8% on average after 68 weeks, compared to 2.3% for those on placebo, the company said

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The mechanism: repeated trauma to the same muscle belly triggers localized inflammatory adipogenesis, where mesenchymal stem cells differentiate into adipocytes in response to tissue injury signals