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Here, we identified a previously unrecognized role of hepatic TH action in modulating the GLP-1 and insulin secretion, which are important for the maintenance of systemic glucose homeostasis

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Tirzepatide, is the active ingredient in Mounjaro for type 2 diabetics and Zepbound for obesity treatment, is a dual glucose-dependent insulinotropic polypeptide (GIP) and a Glucagon-like peptide-1 (GLP-1) receptor agonist

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