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With the treatment target changing from lowering to normalizing ALP many patients with mildly high serum ALP levels (considered nowadays as non-responders) were excluded from these studies

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Clin Pharmacol Ther 2011

The Fenton reaction, in which iron catalyzes the production of reactive oxygen species (ROS) that target polyunsaturated fatty acids (PUFAs) in cell membranes, can cause ferroptosis in endothelial cells