These medications have been extensively studied in large-scale clinical trials and are licensed by the MHRA for specific indications including type 2 diabetes and, in some cases, weight management, as outlined in NICE guidance (NG28)
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doi: 10.1542/peds.2015-3684 550 KothariDPatelSKimS-K
Robust, head-to-head studies are needed to clarify the therapeutic potential and mechanistic diversity of these compounds before their clinical application in DOR management can be meaningfully assessed
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We believe that efforts in these directions will help overcome current challenges and ultimately help develop new immunomodulatory strategies based on Th17/Treg for AR treatment
