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2.4.1 Vascular remodeling In DR, the RhoA/ROCK signaling pathway is activated by high glucose, which leads to endothelial dysfunction, breakdown of the blood-retinal barrier (BRB), and capillary leakage

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When the production of ROS and RNS exceeds the antioxidant defenses, oxidative stress occurs, leading to damage to cellular components including lipids, proteins and deoxyribonucleic acid (DNA)