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Severe cardiac damage occurred when given these mice a high-iron diet and hypertrophic cardiomyopathy, with typical features of ferroptosis, which were rescued by administration of Fer-1 [72]

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BCL2L1 and BCL2 are anti-apoptotic proteins belonging to the BCL2 family that function by preventing the oligomerization of the BAX and BAK proteins and maintaining the integrity of mitochondrial membrane, thus inhibiting cell apoptosis at high expression 37

Hidden cost: Once a gap appears, the behavioral pattern shifts, skip a week because you cannot measure a dose, then reduce intake to avoid nausea, then lose track of when to resume escalation, resulting in the loss of weeks or months of progress