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Both groups followed a reduced-calorie diet, increased physical activity, and monthly nutritional counseling

In one trial, those switched to placebo injections not only began to reaccumulate body fat, but their waist circumference also began to revert back to its original size

The injections are most commonly available as auto-injector pens, in which the medication is preloaded into the pen, and the needle is administered automatically when the injector is pressed against the skin

The most common adverse effects in trials were nausea, vomiting, diarrhoea, and constipation

For patients who have been priced out of GLP-1 treatment, the arrival of a $149 per month oral option from a major manufacturer is the most significant access development since the LillyDirect launch

Insurance coverage for GLP-1 medications varies significantly depending on the indication, specific medication, and insurance plan type