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This slower escalation compared to other medications reflects the triple mechanism requiring more gradual receptor adaptation

These agents exert their effects through distinct yet complementary mechanisms that target key pathways involved in the development and progression of DKD (Fig

This scientific uncertainty directly impacts commercial interest, as developing a drug for a fragmented and unpredictable subpopulation within an already rare disease is a high-risk investment

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Semaglutide has the longest safety record, with data now extending beyond five years in the cardiovascular outcomes trials