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Fertil Steril 2006;85:14204

With the advancement of research, the understanding of COPD etiology has expanded from exposure to harmful gases/particles to multiple etiological types. New classifications of COPD have emerged, including the pulmonary cachexia phenotype, COPD-bronchiectasis overlap phenotype, rapid progressive phenotype, non-smoking COPD phenotype, comorbidity/systemic phenotype, upper lobe-predominant emphysema phenotype, 1-antitrypsin deficiency phenotype, and early disease-related phenotypes (pre-COPD, early-onset COPD, preserved ratio impaired lung function) ( In contrast, an endotype represents the underlying biological or molecular mechanisms that produce these observable traits

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