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This builds on his work to understand 'how circulating GLP-1 can produce multiple actions, both directly and indirectly, on multiple organs' which he has pursued for many years with colleagues (McLean, Wong, Campbell)

Tirzepatide reports nausea in 2533% and vomiting in 16% depending on dose and population studied

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For a 10 mg vial reconstituted to 5 mg/mL, that is 2.0 mL