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Individuals with less-efficient GST variants may experience slower detoxification of oxidative byproducts, potentially benefiting more from increased dietary antioxidant support

This is particularly important for expensive peptides, discontinued products, or compounds with long lead times for replacement

Based on the amount of GSH in the lysate, we calculated the GSH concentration assuming an averaged HeLa/HT1080 cell volume of 4,000 m 3 (refs 15, 51, 52)

Preclinical studies have explored GHK-Cu effects in cardiovascular applications, where the peptide demonstrates capacity to reduce atherosclerotic plaque formation in hyperlipidemic mice through anti-inflammatory effects and improved endothelial function

Others point to dehydration, since increased lipolysis generates metabolic water demands

The medical benefits of APAP are widely recognized