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Diabetes 49 , 19671977 (2000)

Injection Timing and Technique Subcutaneous injection into abdominal fat tissue is the standard route

Mechanistically, calcitriol upregulates key lipid-synthesizing enzymesincluding fatty acid synthase (FAS), 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase), and serine palmitoyltransferase (SPT)and promotes lamellar body maturation and secretion, thereby enhancing stratum corneum structural cohesion [234,235,236]

Effect of exenatide on peripheral nerve excitability in type 2 diabetes

The additional GIP receptor agonism appears to augment insulin secretion further and may contribute to improved lipid metabolism and enhanced satiety signaling

So what was the impetus