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This is neurochemistry

From colorful patches and fruit punch-flavored gummies to prebiotic powders and under-the-tongue tinctures, dietary supplements that claim to complement or supercharge the bodys levels of the gut hormone GLP-1 are a dime a dozen

Since these medications already reduce appetite, a tight fasting window can make it harder to eat enough protein, fiber, calories, and micronutrients

Transdermal delivery of GLP-1 medications faces significant challenges due to the large molecular size of GLP-1 analogs and the skin's natural barrier function

Hormones influence hunger, fat storage, and energy use, so when theyre off, maintaining weight loss after GLP-1 gets tougher

As the image below shows, fat consumption has steadily risen over the last century since we discovered how to extract oil from crops at scale, fuelled by synthetic fertilisers