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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

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Rahmatinejad FZ, Kharat H, Jalili MK, Renani H, Mobasheri

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Given that microvascular dysfunction is a hallmark of cardiovascular aging [59,60,61], our findings position endothelial IGF- 1 signaling as a potential target for preserving peripheral vascular health and muscle performance