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Last Published 01.01.2026 Effective Date: 01.01.2026 This policy addresses dermal filler injections and injectable bulking agents

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Castagn V, Rougemont M, Cunod M, Do KQ

This cellular adaptation typically requires 48 weeks of consistent dosing to produce maximum fasting and postprandial glucose reductions, which is why dose titration schedules span this timeframe

It is also indicated in patients with type 2 diabetes mellitus and established cardiovascular diseases to reduce the risk of adverse cardiovascular events