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Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal, further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly (for parenteral supplementation) or daily (for oral supplementation)

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Symptoms Associated with Urine Color Change & When should you worry about your urine color

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The life cycle of a red blood cell is 90 days, so you will not reach your optimal improvement until after 90 days, when all malformed red blood cells have died off