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For centuries, it has been known that BPH occurs mainly in older men and that it doesn't develop in men whose testes were removed before puberty

The thousands of anecdotal human reports suggest similar effects to animal studies, but formal human clinical trials remain lacking

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DNA evidence from canid remains during these time periods suggests that genes continued to be transferred between these early dogs and wolves

The authors proposed that continual stimulation of sensory nerves during an exacerbation might have led to neuropeptide depletion, thus accounting for the decreased content

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