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Exercise, Metformin, and Healthspan Exercise activates AMPK, which in turn enhances glucose uptake into muscle and improves insulin sensitivity thus helping to offset the negative effects of obesity, diabetes and cardiovascular disease and thereby reducing morbidity and improving healthspan (197)

2007;178(4 Pt 1):1398403 discussion 1403

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Zahedi MJ, Darvish Moghadam S, Hayat Bakhsh Abbasi M, Dehghani M, Shafiei Pour S, Zydabady Nejad H, et al

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1.9.2 Peptide tyrosine-tyrosine Peptide tyrosine-tyrosine is a member of the PP-fold family of peptides, which also includes the anorexigenic PP and the orexgenic neurotransmitter NPY, all sharing a common tertiary structure