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Additional information Peer review information Nature Communications thanks the anonymous reviewer(s) for their contribution to the peer review of this work

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Consider Clinical Trial Enrollment If you meet the eligibility criteria and live near a trial site, clinical trial enrollment gives you free access to pharmaceutical-grade retatrutide under close medical supervision

Most participants tolerate this step with minimal new symptoms

4,18 Data suggest that dulaglutide and liraglutide may be associated with higher rates of nausea, vomiting, and constipation compared with semaglutide, whereas pharmacovigilance analyses indicate that semaglutide carries the greatest signal strength for these AEs

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