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In collaboration with Steno Diabetes Center, we also plan to analyze blood samples from patients who have either received GLP-1-based treatment or undergone bariatric surgery, to see whether one of these approaches has a stronger effect on inflammation more broadly

Why This Work Matters: This work demonstrates the strength of a 2D-LC-MS strategy, combining non-denaturing AEX with denaturing IP-RPLC-MS, for robust diastereomer separation and comprehensive impurity profiling supporting improved control and characterization of antisense, siRNA, and lipid-conjugated oligonucleotide therapeutics