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At the start of the study, the median baseline body mass index among study participants was 38.5

The results gradually improve over several weeks and months

Discussion There are several reports on the effects of GLP-1RA on the gut microbiota in rodents 26,27,28

Clinical research has shown that GLP-1based weight management programs, when combined with lifestyle modifications such as nutrition and movement, can lead to meaningful weight loss and improvements in metabolic health

While GLP-1s have demonstrated efficacy in reducing obesity-related complications, observational data and case reports from gastroenterology literature raise flags regarding potential UC flares or symptom worsening

Laboratory studies demonstrate that the peptide was engineered as a fusion with HIV-TAT, a basic and hydrophilic sequence that enables energy-independent cellular uptake, ensuring effective intracellular delivery for precise molecular targeting in experimental settings