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Wang MT, Bolland MJ, Grey A

Obesity and Comorbidities in Patients With PWS The clinical picture is complex and varies considerably across the life stages: axial hypotonia, inability to suck, and hypothermia are common at birth, and often require prolonged incubation and use of nasogastric or gastric tube to provide adequate nutrition and to avoid short stature and/or decreased growth velocity [9]

The tapering approach essentially reverses the standard treatment protocol for GLP1s, which typically involves gradually increasing the dose over time

Most patients tolerate this minor adjustment without significant issues, though staying hydrated and eating small, protein-rich meals can help manage any temporary nausea

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US Patent 7,208,604 "From DEA website, accessed 23 Jan 2007"