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GSH redox dynamics have been included within kinetic models for metabolism of fungi 38 , yeast 39 , erythrocytes 40 , and liver 41,42,43,44,45,46 , kidney 47 , immune 48 and cancer cells 49,50

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In a large, rigorous review of over 50 studies involving more than one million patients, metformin use in patients with type 2 diabetes was associated with a 35% reduction in risk of death from cancer, and a 27% reduction in risk of any cancer (Franciosi 2013)

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Compared with that in younger mice, the efficacy of the JAK inhibitor ruxolitinib in aged mice is superior, manifesting in the clearance of SnCs, enhancement of physical performance, and maintenance of adipose tissue homeostasis (Table 1)