Whether the additional glucagon receptor activity of retatrutide contributes to a higher rate of gastrointestinal side effects compared with GLP-1 monotherapy has not yet been established in head-to-head studies, and any such comparison should be interpreted cautiously
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We believe this reflects the increased proportion of GLP-1 prescriptions among younger non-diabetic individuals
BPC-157 remains investigational by comparison, with animal data suggesting potential but no controlled human trials confirming cardiovascular benefits
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